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Vitamin B6 (pyridoxine): Vitamin B6 must be present to facilitate conversion of either 5-HTP or tryptophan into serotonin (17, 18).Often 5-HTP or tryptophan supplements also contain B6 for this reason.Serotonin supplements like specific amino acids, vitamins, minerals and herbs increase serotonin levels helping depression and other brain-related disorders.Serotonin is a neurotransmitter that plays a large role in mood, learning, appetite control, and sleep.Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.

For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.Sometimes there are vital synergistic relationships between these various serotonin boosting substances.A review of 108 studies on 5-HTP revealed there is still no definitive evidence that it helps depression (9). An Ongoing Debate: There’s an ongoing discussion in the natural health community whether it’s better to take tryptophan or 5-HTP to increase serotonin levels.Tryptophan more readily enters the brain, but 5-HTP requires one less step to convert into serotonin.

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